Ma M, Ardalan A, Van Dyk A, Charles TC, Horsman GP (2024) Discovery of a glyphosate oxidase in nature FEMS Microbiology Letters, 371:fnae086.
Awarded best article of 2024
Ramos-Figueroa JS, Palmer DRJ, Horsman GP (2022) Phosphoenolpyruvate mutase-catalyzed C–P bond formation: mechanistic ambiguities and opportunities ChemBioChem, 23:e202200285.
Li S, Horsman GP (2022) An inventory of early branch points in microbial phosphonate biosynthesis Microbial Genomics, 8:000781.
Li P, Chen M, Tang W, Guo Z, Zhang Y, Wang M, Horsman GP, Zhong J, Lu Z, Chen Y (2021) Initiating polyketide biosynthesis by on-line methyl esterification Nature Communications 12, 4499
Ding Y, Li X, Horsman GP, Li P, Wang M, Li J, Zhang Z, Liu W, Wu B, Tao Y, Chen Y (2021) Construction of an alternative NAD+ de novo biosynthesis pathway Advanced Science 202004632
Wang D, Qi J, Han W, Gao JM, Horsman GP (2020) Kanamycin-induced production of 2’,3’-cyclic AMP in Escherichia coli Biochemical and Biophysical Research Communications 527, 854-860
Yan Y, Yang J, Wang L, Xu D, Yu Z, Guo X, Horsman GP, Lin S, Tao M, Huang S-X (2020) Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase Chemical Science 11, 3959-3964
Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP (2019) The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis Nature Communications 10, 3698
Hao T, Xie Z, Wang M, Liu L, Zhang Y, Wang W, Zhang Z, Zhao X, Li P, Guo Z, Gao S, Lou C, Zhang G, Merritt J, Horsman GP, Chen Y (2019) An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters Nature Communications 10, 3665
Guo X, Crnovcic I, Chang C-Y, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B (2018) PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates Biochemistry 57, 1003-1011
Huitema C, Horsman GP (2018) Analyzing enzyme kinetic data using the powerful statistical capabilities of R bioRxiv doi.org/10.1101/316588
Bartlett C, Bansal S, Burnett A, Suits MD, Schaefer J, Cegelski L, Horsman GP, Weadge JT (2017) Whole-cell detection of C-P bonds in bacteria Biochemistry 56, 5870-5873.
Horsman GP, Zechel DL (2017) Phosphonate biochemistry Chemical Reviews 117, 5704-5783
Liu L, Hao T, Xie Z, Horsman GP, Chen Y (2016) Genome mining reveals widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans Scientific Reports 6, 37479
Yan Y, Yang J, Yu Z, Yu M, Ma Y-T, Wang L, Su C, Luo J, Horsman GP, Huang S-X (2016) Non-enzymatic pyridine ring foramtion in the biosynthesis of the rubrolone tropolone alkaloids Nature Communications 7, 13083
Yan Y, Ma Y-T, Yang J, Horsman GP, Luo D, Ji X, Huang S-X (2016) Tropolone ring construction in the biosynthesis of rubrolone B, a cationic tropolone alkaloid from endophytic Streptomyces Organic Letters 18, 1254-1257
Chi MC, Horsman GP (2015) Evaporative light-scattering quantification of natural products possessing a carbon-phosphorus bond Journal of Antibiotics 68, 752-756
Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B (2013) Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics Biochemistry 52, 5217-5224
Lohman JR, Huang S-X, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B (2013) Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics Molecular BioSystems 9, 478-491
Ruzzini AC, Horsman GP, Eltis LD (2012) The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage Biochemistry 51, 5831-5840
Lin S, Huang T, Horsman GP, Huang S-X, Guo X, Shen B (2012) Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis Organic Letters 14, 2300-2303
Ruzzini AC, Ghosh S, Horsman GP, Foster LJ, Bolin JT, Eltis LD (2012) Identification of an acyl-enzyme intermediate in meta-cleavage product hydrolase reveals the versatility of the catalytic triad Journal of the American Chemical Society 134, 4615-4624
Chen Y, Yin M, Horsman GP, Shen B (2011) Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus Journal of Natural Products 74, 420-424
Ling J, Horsman GP, Huang S-X, Luo Y, Lin S, Shen B (2010) Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate Journal of the American Chemical Society 132, 12534-12536
Lin S, Horsman GP, Shen B (2010) Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster Organic Letters 12, 3816-3819
Chen Y, Yin M, Horsman GP, Huang S-X, Shen B (2010) Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027 Journal of Antibiotics 63, 482-485
Horsman GP, Chen Y, Thorson JS, Shen B (2010) Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes Proceedings of the National Academy of Sciences of the United States of America 107, 11331-11335
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD (2010) Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism Journal of Biological Chemistry 285, 434-443
Lin S, Horsman GP, Chen Y, Li W, Shen B (2009) Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis Journal of the American Chemical Society 131, 16410-16417
Van Lanen SG, Lin S, Horsman GP, Shen B (2009) Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027 FEMS Microbiology Letterrs 300, 237-241
Horsman GP, Van Lanen SG, Shen B (2009) Iterative type I polyketide synthases for enediyne core biosynthesis Methods in Enzymology 459, 97-112
Bhowmik S, Horsman GP, Bolin JT, Eltis LD (2007) The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization Journal of Biological Chemistry 282, 36377-36385
Horsman GP, Bhowmik S, Seah SYK, Kumar P, Bolin JT, Eltis LD (2007) The tautomeric half-reaction of BphD, a C-C bond hydrolase: kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad Journal of Biological Chemistry 282, 19894-19904
Seah SYK, Ke J, Denis G, Horsman GP, Fortin PD, Whiting CJ, Eltis LD (2007) Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyls Journal of Bacteriology 189, 4038-4045
Horsman GP, Ke J, Dai S, Seah SYK, Bolin JT, Eltis LD (2006) Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway Biochemistry 45, 11071-11086
Fortin PD, Horsman GP, Yang HM, Eltis LD (2006) A glutathione S-transferase catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls Journal of Bacteriology 188, 4424-4430
Horsman GP, Jirasek A, Vaillancourt FH, Barbosa CJ, Jarzecki AA, Xu C, Mekmouche Y, Spiro TG, Lipscomb JD, Blades MW, Turner RFB, Eltis LD (2005) Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase Journal of the American Chemical Society 127, 16882-16891
Park S, Morley KL, Horsman GP, Holmquist M, Hult K, Kazlauskas RJ (2005) Focusing mutations into the P. fluorescens esterase binding site increases enantioselectivity more effectively than distant mutations Chemistry & Biology 12, 45-54
Jirasek A, Horsman GP, Vaillancourt FH, Barbosa CJ, Eltis LD, Blades MW, Turner RFB (2004) Probing enzyme-substrate interactions using fiber-optic ultraviolet resonance Raman spectroscopy American Pharmaceutical Review 7, 49-53
Horsman GP, Liu AMF, Henke E, Bornscheuer UT, Kazlauskas RJ (2003) Mutations in distant residues moderately increase the enantioselectivity of Pseudomonas fluorescens esterase towards methyl 3-bromo-2-methylpropanoate and ethyl 3-phenylbutyrate Chemistry-A European Journal 9, 1933-1939
Liu AMF, Somers NA, Kazlauskas RJ, Brush TS, Zocher F, Enzelberger MM, Bornscheuer UT, Horsman GP, Mezzetti A, Schmidt-Dannert C, Schmid RD (2001) Mapping the substrate selectivity of new hydrolases using colorimetric screening: lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas fluorescens and Streptomyces diastatochromogenes Tetrahedron: Asymmetry 12, 545-556
Beriault JN, Horsman GP, Devine MD (1999) Phloem transport of D,L-glufosinate and acetyl-L-glufosinate in glufosinate-resistant and -susceptible Brassica napus Plant Physiology 121, 619-628
Hall LM, Stromme KM, Horsman GP, Devine MD (1998) Resistance to acetolactate synthase inhibitors and quinclorac in a biotype of false cleavers (Galium spurium) Weed Science 46, 390-396